s-plus 6.0 interface to nonmem version v (Insightful Corp)
90
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Insightful Corp
s-plus 6.0 interface to nonmem version v
S Plus 6.0 Interface To Nonmem Version V, supplied by Insightful Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s-plus+6%2E0+interface+to+nonmem+version+v/s+plus+6+0+interface+to+nonmem+version+v/pm20020526-76-1-5
Average 90 stars, based on 1 article reviews
S Plus 6.0 Interface To Nonmem Version V, supplied by Insightful Corp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/s-plus+6%2E0+interface+to+nonmem+version+v/s+plus+6+0+interface+to+nonmem+version+v/pm20020526-76-1-5
Average 90 stars, based on 1 article reviews
s-plus 6.0 interface to nonmem version v - by Bioz Stars,
2026-10
90/100 stars
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other:Article Title: Effect of altered AGP plasma binding on heart rate changes by S(-)-propranolol in rats using mechanism-based estimations of in vivo receptor affinity (K(B,vivo)). Article Snippet: Journal of Pharm 2009 Wiley-Liss ABSTRACT: In contrast to the impact of plasma protein binding on pharmacokinetics, no quantitative in vivo information is available on its impact on pharmacodynamics.. The pharmacokinetic–pharmacodynamic relationship of the model drug S( )-propranolol was evaluated using mechanism-based estimations of in vivo receptor affinity (KB,vivo), under conditions of altered plasma protein binding resulting from different levels of alpha-1-acid glycoprotein (AGP).. Male Wistar Kyoto rats with isoprenaline-induced tachycardia received an intravenous infusion of S( )-propranolol, on postsurgery day 2 (n1⁄4 7) and day 7 (n1⁄4 8) with elevated and normal plasma protein binding, respectively. Article Title: Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats. Article Snippet: The purpose of this investigation was to develop a mechanismbased pharmacokinetic/pharmacodynamic (PK/PD) model to predict the time course of respiratory depression following administration of opioids in rats.. The proposed model is based on receptor theory and aims at the separate characterization of biophase distribution and receptor association/dissociation kinetics as determinants of hysteresis between plasma concentration and effect.. Individual concentration time courses of buprenorphine and fentanyl were determined in conjunction with continuous monitoring of respiratory depression. Article Title: Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics. Article Snippet: The objective of this investigation was to characterize the pharmacokinetic/pharmacodynamic correlation of buprenorphine and fentanyl for the antinociceptive effect in rats.. Data on the time course of the antinociceptive effect following intravenous administration of buprenorphine or fentanyl was analyzed in conjunction with plasma concentrations by nonlinear mixedeffects analysis.. For fentanyl, the pharmacokinetics was described on the basis of a two-compartment pharmacokinetic model. For buprenorphine, a three-compartment pharmacokinetic model best described the concentration time course. Article Title: Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach. Article Snippet: 3816 JOURN ABSTRACT: The objective of this investigation was to examine in a systematic manner the influence of plasma protein binding on in vivo pharmacodynamics.. Comparative pharmacokinetic–pharmacodynamic studies with four b blockers were performed in conscious rats, using heart rate under isoprenaline-induced tachycardia as a pharmacodynamic endpoint.. A recently proposed mechanism-based agonist–antagonist interaction model was used to obtain in vivo estimates of receptor affinities (KB,vivo). Article Title: Pharmacokinetic-pharmacodynamic modelling of S (−)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint Article Snippet: An |